Named in honor of a revered Cherokee leader, Tsali Notch Vineyard is a distinctive East Tennessee vineyard located in the heart of Monroe County, nestled within the Tennessee Overhill Heritage Area. Just off the scenic Cherohala Skyway, this 202-acre vineyard invites visitors to experience the rich history, breathtaking landscapes, and bold flavors of America’s Wild Grape: the muscadine.

With more than 6,000 muscadine vines growing across 21 miles of trellis, Tsali Notch is one of the region’s premier destinations for muscadine wine lovers and those seeking a true taste of Southern viticulture. Surrounded by panoramic mountain views, the vineyard showcases six unique muscadine varieties, including red (dark) cultivars like Nesbit and Noble, and white (bronze) favorites such as Carlos, Doreen, Magnolia, and Sterling.

Muscadines are more than just delicious—they’re also known for being among the highest in health-boosting antioxidants, particularly resveratrol. Whether you’re sipping our handcrafted wines, enjoying a fresh-picked grape, or creating your own juice or jelly, you’re experiencing the full nutritional and cultural value of this native Southern fruit.

Visitors to Tsali Notch Vineyard can enjoy more than just wine. The estate also serves as a charming venue for weddings, family reunions, and special events, featuring facilities like the rustic Party Barn, the inviting tasting room, and The Jackson Lounge—a beautifully restored 19th-century farmhouse ideal for gatherings of all kinds.

Each fall, guests are welcomed to participate in our annual U-pick muscadine harvest, where you can pick grapes straight from the vine and enjoy a hands-on connection to the vineyard’s bounty. It’s a festive time filled with community, celebration, and the timeless joy of the harvest season.

Whether you’re exploring the Cherohala Skyway, planning an event in the Smoky Mountain region, or simply seeking authentic Tennessee muscadine wine, Tsali Notch Vineyard invites you to savor the legacy and flavor of America’s Wild Grape—in every bottle, every glass, and every unforgettable experience.